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Adrian Baez-Ortega

Adrian Baez-Ortega

PhD student (2015–2019)


Biography:

Adrian is currently a postdoctoral researcher at the Wellcome Sanger Institute, where he investigates the biological processes moulding the evolution of cells in healthy and diseased tissues. He was a PhD student at the Transmissible Cancer Group from 2015 to 2019. Before moving to Cambridge, Adrian obtained first-class honours BSc and MSc degrees in Computer Science at the University of La Laguna, Spain. After two research internships, he commenced his PhD under the supervision of Prof Elizabeth Murchison in 2015.

For his doctoral work, which investigated the evolution of CTVT, a parasitic transmissible cancer that has affected dog populations for several millennia, Adrian received honours including the 2020 Harold M. Weintraub Graduate Student Award, the 2019 Kennel Club Charitable Trust Postgraduate Student Inspiration Award, and the 2017 Abcam Postgraduate Research Prize. His research on CTVT has been featured in prominent international media platforms, including WIRED, The Atlantic, The Times, Gizmodo, El País and The Hindu.

Adrian's side interests include literature, physics, philosophy, and the history of science. He also writes for his two blogs, divulgatum and in silico.

See Adrian's profile on Google Scholar | LinkedIn | Publons.

Key Publications

A Baez-Ortega, K Gori, A Strakova, JL Allen, KM Allum, L Bansse-Issa, TN Bhutia, JL Bisson, C Briceño, A Castillo Domracheva, AM Corrigan, HR Cran, JT Crawford, E Davis, KF de Castro, AB de Nardi, AP de Vos, L Delgadillo Keenan, EM Donelan, AR Espinoza Huerta, IA Faramade, M Fazil, E Fotopoulou, SN Fruean, F Gallardo-Arrieta, O Glebova, PG Gouletsou, RF Häfelin Manrique, JJGP Henriques, RS Horta, N Ignatenko, Y Kane, C King, D Koenig, A Krupa, SJ Kruzeniski, YM Kwon, M Lanza-Perea, M Lazyan, AM Lopez Quintana, T Losfelt, G Marino, S Martínez Castañeda, MF Martínez-López, M Meyer, EJ Migneco, B Nakanwagi, KB Neal, W Neunzig, M Ní Leathlobhair, SJ Nixon, A Ortega-Pacheco, F Pedraza-Ordoñez, MC Peleteiro, K Polak, RJ Pye, JF Reece, J Rojas Gutierrez, H Sadia, SK Schmeling, O Shamanova, AG Sherlock, M Stammnitz, AE Steenland-Smit, A Svitich, LJ Tapia Martínez, I Thoya Ngoka, CG Torres, EM Tudor, MG van der Wel, BA Viţălaru, SA Vural, O Walkinton, J Wang, AS Wehrle-Martinez, SAE Widdowson, MR Stratton, LB Alexandrov, I Martincorena, EP Murchison
Science, 365, eaau9923 (2019)
DOI: 10.1126/science.aau9923
 

Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
A Strakova, TJ Nicholls*, A Baez-Ortega*, M Ní Leathlobhair, AT Sampson, K Hughes, IAG Bolton, K Gori, J Wang, I Airikkala-Otter, JL Allen, KM Allum, CL Arnold, L Bansse-Issa, TN Bhutia, JL Bisson, K Blank, C Briceño, A Castillo Domracheva, AM Corrigan, HR Cran, JT Crawford, SM Cutter, E Davis, KF de Castro, AB De Nardi, AP de Vos, L Delgadillo Keenan, EM Donelan, AR Espinoza Huerta, IA Faramade, M Fazil, E Fotopoulou, SN Fruean, F Gallardo-Arrieta, O Glebova, PG Gouletsou, RF Häfelin Manrique, JJGP Henriques, RS Horta, N Ignatenko, Y Kane, C King, D Koenig, A Krupa, SJ Kruzeniski, M Lanza-Perea, M Lazyan, AM Lopez Quintana, T Losfelt, G Marino, S Martínez Castañeda, MF Martínez-López, BM Masuruli, M Meyer, EJ Migneco, B Nakanwagi, KB Neal, W Neunzig, SJ Nixon, A Ortega-Pacheco, F Pedraza-Ordoñez, MC Peleteiro, K Polak, RJ Pye, JC Ramirez-Ante, JF Reece, J Rojas Gutierrez, H Sadia, SK Schmeling, O Shamanova, AG Sherlock, AE Steenland-Smit, A Svitich, LJ Tapia Martínez, I Thoya Ngoka, CG Torres, EM Tudor, MG van der Wel, BA Vițălaru, SA Vural, O Walkinton, AS Wehrle-Martinez, SAE Widdowson, I Zvarich, PF Chinnery, M Falkenberg, CM Gustafsson, EP Murchison
Nature Communications, 11 (1): 3059 (2020)
DOI: 10.1038/s41467-020-16765-w
*Equal contribution

Pan-cancer analysis of whole genomes reveals driver rearrangements promoted by LINE-1 retrotransposition
B Rodriguez-Martin, EG Alvarez*, A Baez-Ortega*, J Zamora, F Supek, J Demeulemeester, M Santamarina, YS Ju, J Temes, D Garcia-Souto, H Detering, Y Li, J Rodriguez-Castro, A Dueso-Barroso, AL Bruzos, SC Dentro, MG Blanco, G Contino, D Ardeljan, M Tojo, ND Roberts, S Zumalave, PAW Edwards, J Weischenfeldt, M Puiggros, Z Chong, K Chen, EA Lee, JA Wala, K Raine, A Butler, SM Waszak, FCP Navarro, SE Schumacher, J Monlong, F Maura, N Bolli, G Bourque, M Gerstein, PJ Park, D Wedge, R Beroukhim, D Torrents, JO Korbel, I Martincorena, RC Fitzgerald, P Van Loo, HH Kazazian, KH Burns, PJ Campbell, JMC Tubio
Nature Genetics, 52(3): 306–319 (2020)
DOI: 10.1038/s41588-019-0562-0
*Equal contribution

sigfit: flexible Bayesian inference of mutational signatures
K Gori, A Baez-Ortega
bioRxiv (2018)
DOI: 10.1101/372896

The origins and vulnerabilities of two transmissible cancers in Tasmanian devils
MR Stammnitz, THH Coorens, KC Gori, D Hayes, B Fu, J Wang, DE Martin-Herranz, LB Alexandrov, A Baez-Ortega, S Barthorpe, A Beck, F Giordano, GW Knowles, YM Kwon, G Hall, S Price, RJ Pye, JMC Tubio, HVT Siddle, S Singh Sohal, GM Woods, U McDermott, F Yang, MJ Garnett, Z Ning, EP Murchison
Cancer Cell, 33(4): 607–619 (2018)
DOI: 10.1016/j.ccell.2018.03.013

Computational approaches for discovery of mutational signatures in cancer
A Baez-Ortega, K Gori
Briefings in Bioinformatics, 20(1): 77–88 (2017)
DOI: 10.1093/bib/bbx082

Human anti-cancer drugs could help treat transmissible cancers in Tasmanian devils

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