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Transmissible cancers mentioned in the New York Times

last modified Mar 06, 2016 07:27 PM

TCG research was mentioned in a recent article in the New York Times, speculating about transmissible cancers in humans...

 http://www.nytimes.com/2016/02/23/science/scientists-ponder-the-prospect-of-contagious-cancer.html?_r=1

Greetings from Mirjam after her visit to TCG

last modified Feb 23, 2016 11:19 AM

Last week (1st-5th February) I had the privilege of visiting the TCG group at the Department of Veterinary Medicine in Cambridge, UK.

I had an awesome week!

 

In my normal life I am a vet who works for a welfare organisation in Port Elizabeth, South Africa. I work in a small clinic where I deal with vaccinations, basic treatment of animal illness and injuries and simple surgery (predominantly spaying). I see and treat TVT regularly and since 2013 I have been sending biopsies to Andrea. Until now, sending regular biopsies was the extent of my involvement with the CTVT project. But after this week, I feel more like I'm part of a team!

 

Sitting in the lab in Cambridge and cutting up the pieces of tumour that I had actually collected, made me see how I fitted in the whole picture. From the way I label the biopsy vials, the information I send, the pictures I take to the point where I treat the patient. And in discussion with Liz and Tracy and Andy, I soon realised how little things that I can do (clinical history, location of the dog, exact treatment protocol etc) can make a considerable difference to how the results are interpreted.

I had been asked to do a presentation for the lab describing my field work. Initially I was wondering how I could relate to my audience but it turned out to be very easy to share my veterinary ideas and experiences with the group and for them to make suggestions about more field based information gathering. It all came together very nicely!

 

My very comfortable accommodation was at King's College, right in the heart of old Cambridge. The place oozes history and it's difficult not to be impressed by it.

The week wasn't just in the laboratory. I was given a guided tour of the Queen’s Veterinary School Hospital by the Dean of the Vet School Professor Mike Herrtage, I also went to other departmental presentations. We did lunch, we did dinner and it was over before I had a chance to breathe!

 

Liz, Tracy, Andy, Max, Young Mi, Adrian, Maire and Issy, thank you all for an unforgettable week!

 

Warm regards,

Mirjam

Dr Mirjam van der Wel from AACL, South Africa visited TCG

last modified Feb 09, 2016 11:47 AM

Dr Mirjam van der Wel, from Animal Anti-Cruelty League (AACL) South Africa, came to visit TCG last week. Mirjam is a collaborator of our ongoing CTVT projects and had sent us hundreds of CTVT samples in the past few years. She spent a week with TCG members and investigated the journey of CTVT tissue samples from the biopsy to genomic DNA sequencing. 

Mission completed! TCG members back from an exciting Tasmania field excursion

last modified Jan 28, 2016 11:12 AM

Over the past three weeks, our enthusiastic TCG members have been on a field excursion to Australia’s southernmost state: ’Tassie devil’s habitat. With the recent discovery of a second DFTD lineage, their intention was to conduct a preliminary field assessment of the spread DFT2 and meet local collaborators of the Save the Devil program.

Bringing Tasmanian summer, many unique memories and devil stories in
their suitcases, the three have now safely arrived in Cambridge: welcome back!

A second transmissible cancer in Tasmanian devils

last modified Jan 04, 2016 01:32 AM

Scientists at the TCG, together with collaborators at the University of Tasmania and the Save the Tasmanian Devil Program, have discovered a second transmissible cancer in Tasmanian devils. This second cancer, known as Devil Facial Tumour 2 (DFT2), causes tumours that are grossly indistinguishable from the first-discovered transmissible cancer in Tasmanian devils (now known as DFT1). However, DFT2 bears no detectable genetic similarity to DFT1. This astonishing discovery has just been published in Proceedings of the National Academy of Science. Further information is also available on the University of Cambridge website.

TCG Christmas Party!

last modified Dec 12, 2015 04:59 PM

The 2015 TCG Christmas Party was complete with German mulled wine, Chinese dumplings, Korean pickled cabbage pancakes, Czech spinach pastry, an Irish casserole, a brussels sprouts extravaganza and, most importantly, a TCG cake (see photo)! There was also a visit by Secret Santa, who brought lots of interesting gifts, including a shining reindeer nose T-shirt. 

Congratulations Karina Ferreira de Castro!

last modified Dec 08, 2015 06:00 PM

Karina Ferreira de Castro, a PhD student from São Paulo State University who visited the TCG in 2014, has successfully defended her PhD thesis in Brazil. Karina is also a veterinary oncologist, who regularly treats CTVT cases. Her thesis was entitled “Canine transmissible venereal tumour – I. Gene and protein expression and genotypic characterization of DLADQA-1 (MHC-II); II. Immunohistochemistry evaluation of local immune response”. Congratulations, Karina!

Prof Kathy Belov visits the TCG

last modified Nov 11, 2015 07:32 PM

Professor Kathy Belov, from the University of Sydney, came to visit the TCG this week. Kathy is a colleague working on Tasmanian devils and other Australian species.

TCG welcomes new group member Tracy Wang

last modified Nov 11, 2015 12:07 PM

Welcome to new TCG group member Dr Tracy Wang, who has joined us today! Tracy will take the role of Lab Manager / Project coordinator. Welcome, Tracy! 

TCG research highlighted on University of Cambridge website

last modified Nov 04, 2015 10:39 AM

Research from the TCG has been highlighted on the University of Cambridge website in an article entitled “T is for Tasmanian devil”. This article is part of an “animal alphabet” which looks at a selection of different animals featuring in research at Cambridge.

Elizabeth Murchison receives Honourable Mention for 2016 Rosalind Franklin Young Investigator Award

last modified Nov 04, 2015 10:36 AM

Elizabeth Murchison has been named runner-up for the 2016 Genetics Society of America (GSA) Rosalind Franklin Young Investigator Award of the Gruber Foundation. The award is to honour the ground-breaking contributions of Dr Rosalind Franklin in genetics research and to inspire and support new generations of women in the field of genetics.

TCG Spanish dinner to farewell Jose Tubio

last modified Oct 21, 2015 12:51 PM
TCG Spanish dinner to farewell Jose Tubio

TCG Spanish evening

The TCG had a farewell dinner for Jose Tubio, who is returning to Spain next week. Jose will be starting his own group at the University of Vigo. We wished him farewell with (not-so-authentic) Spanish tapas.

New position available within the Transmissible Cancer Group

last modified Aug 19, 2015 10:38 AM

A new position is available for a Research Laboratory Technician within the Transmissible Cancer Group. This role is an exciting opportunity to get involved in research on transmissible cancers in both dogs and Tasmanian devils! More information available here:

http://www.jobs.cam.ac.uk/job/7847/

Andrea Strakova wins Kennel Club award for best student talk

last modified Jun 26, 2015 03:05 PM

Congratulations to Andrea Strakova, who has been awarded a £500 prize for delivering the best student talk at the Advances in Canine and Feline Genomics Conference! Andrea’s talk was entitled “Tracing the evolution and worldwide spread of the canine transmissible venereal tumour”. Andrea was also awarded a prize for submitting one of the best student abstracts at the conference. Congratulations, Andy!

Transmissible Cancer Group members present at Canine Genome Conference

last modified Jun 24, 2015 09:48 PM

Andrea Strakova and Elizabeth Murchison both gave presentations at the International Conference on Advances in Canine an Feline Genomics and Inherited Diseases, held in Cambridge from 23rd to 26th June. The photo shows Andrea giving her talk, entitled “Tracing the evolution and worldwide spread of the canine transmissible venereal tumour”.

Jose Tubio awarded prestigious fellowship

last modified Jun 21, 2015 11:43 AM

Congratulations to Jose Tubio, who has received a prestigious Ramón y Cajal Fellowship from the Spanish Government. We celebrated at the Eagle Pub, where DNA was announced. This is an enormous achievement, many congratulations, Jose!

Three new members of Transmissible Cancer Group

last modified Jun 04, 2015 04:42 PM

Adrian Baez-Ortega, Max Stammnitz and Daniel Martin-Herranz recently joined the Transmissible Cancer Group for summer 2015. Max and Daniel are part of the Cambridge MPhil in Computational Biology, and Adrian is a visiting researcher from Spain. Adrian, Max and Daniel are analysing transmissible cancer genomes in both dogs and devils.

Transmissible cancer mini-symposium in Southampton

last modified May 12, 2015 08:27 PM

We had a day-long mini-symposium on transmissible cancers with our collaborators at the University of Southampton. On the way home we had Red Velvet cake at King's Cross station.

Welcome new Transmissible Cancer Group member Jose Tubio

last modified May 01, 2015 05:54 PM

Dr Jose Tubio joined our group today as a new Postdoctoral Research Associate. Jose will be investigating genome evolution in DFTD and CTVT. Welcome, Jose!

A third transmissible cancer found in clams

last modified Apr 16, 2015 09:44 PM

Contagious cancers may be more common than expected - researchers from Columbia University have just discovered a third transmissible cancer, affecting soft-shell clams on the East Coast of North America. Clam disseminated neoplasia, a leukemia-like disease, has been known for years and was previously thought to be caused by a virus; but now it is clear that it is transmitted by the cancer cells themselves. To celebrate the discovery of a new infectious cancer, we tested out the clams in a local restaurant…

clam newsThe full citation for the new paper is: Michael J. Metzger, C. Reinisch, J. Sherry, Stephen P. Goff, Horizontal Transmission of Clonal Cancer Cells Causes Leukemia in Soft-Shell Clams. Cell 161, 255-263 10.1016/j.cell.2015.02.042

New review on CTVT published by our group

last modified Apr 13, 2015 09:41 AM

A new review entitled “The cancer which survived: insights from the genome of an 11 000 year-old cancer” has just been published by our group in Current Opinion in Genetics and Development! If you would be interested in reading more about canine transmissible venereal tumour and the adaptations which it has acquired as a long-lived lineage, you can read the whole article here.

Strakova A and Murchison EP The cancer which survived: insights from the genome of an 11,000 year-old cancer. Curr Opin Genet Dev. 30:49-55 (2015)

Congratulations to our collaborator Mayra Martinez!

last modified Mar 25, 2015 10:35 PM

Mayra Martinez, our CTVT collaborator in Ecuador, passed her thesis viva today with a perfect score of 10/10. Mayra performed her thesis research on physiological changes triggered by CTVT in dogs. Congratulations, Mayra!

New Transmissible Cancer Group website launches

last modified Mar 20, 2015 10:25 AM

Today the Transmissible Cancer Group website was launched at the Vet School.

Canine Transmissible Venereal Disease

VIDEO: The contagious cancer that conquered the world

last modified May 17, 2016 01:28 PM
VIDEO: The contagious cancer that conquered the world

Aboriginal camp dogs in northern Australia. Photo courtesy of AMRRIC.

A short video describing our work on the genetics of canine transmissible venereal tumour - the world’s oldest cancer - which was published in eLife today, can be found here. We hope that you will find it interesting!

 

Human anti-cancer drugs could help treat transmissible cancers in Tasmanian devils

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