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Dr Tracy Wang PhD

Dr Tracy Wang, PhD

Lab manager / Project coordinator


Office Phone: +44 1223 339376

Biography:

Tracy was an Associated Professor in Microbiology at Nankai University, China before she came to Cambridge.  She did her PhD jointly in Nankai University and Bayer Crop Science, Belgium on investigating the diversity of Bacillus thuringiensis in China and identification of novel cry genes.  In 2003, she was awarded a Wellcome Trust International Fellowship and joined Professor David Ellar’s group at Department of Biochemistry, University of Cambridge worked on the project of “Virulence mechanisms in the pathogenesis of the Bacillus cereus group”. Tracy moved to Professor Duncan Maskell's group at the Department of Veterinary Medicine in 2006 as research associate and involved in various projects including developing Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry, genome-wide analysis of Salmonella infecting livestock hosts, she was one of the leading scientists of a BBSRC LOLA project on developing vaccine and diagnostic platform of respiratory pathogens in pigs, mainly focus on Streptococcus suis. Tracy was also an external coordinator of Master Program at the Institute of Biotechnology, University of Granada, Spain since 2010. In November 2015, Tracy joined Dr. Elizabeth Murchison’s group as the lab manager/project coordinator. At her spare time, Tracy enjoys walking in the countryside and exploring the nature.

Key Publications

  1. Weinert LA, Chaudhuri RR, Wang J, Peters SE, Corander J, Jombart T, Baig A, Howell KJ, Vehkala M, Välimäki N, Harris D, Chieu TT, Van Vinh Chau N, Campbell J, Schultsz C, Parkhill J, Bentley SD, Langford PR, Rycroft AN, Wren BW, Farrar J, Baker S, Hoa NT, Holden MT, Tucker AW, Maskell DJ; BRaDP1T Consortium. 2015. Genomic signatures of human and animal disease in the zoonotic pathogen Streptococcus suis. Nature Communications.  Mar 31;6:6740.
  2. Howell KJ, Peters SE, Wang J, Hernandez-Garcia J, Weinert LA, Luan SL, Chaudhuri RR, Angen Ø, Aragon V, Williamson SM, Parkhill J, Langford PR, Rycroft AN, Wren BW, Maskell DJ, Tucker AW. 2015. Development of a Multiplex PCR Assay for Rapid Molecular Serotyping of Haemophilus parasuis. J Clin Microbiol. Dec;53(12):3812-21.
  3. Baig A, Weinert LA, Peters SE, Howell KJ, Chaudhuri RR, Wang J, Holden MT, Parkhill J, Langford PR, Rycroft AN, Wren BW, Tucker AW, Maskell DJ. 2015.  Whole genome investigation of a divergent clade of the pathogen Streptococcus suis. Front Microbiol. Nov 4;6:1191. eCollection 2015.
  4. Chaudhuri RR, Morgan E, Peters SE, Pleasance SJ, Hudson DL, Davies HM, Wang J, van Diemen PM, Buckley AM, Bowen AJ, Pullinger GD, Turner DJ, Langridge GC, Turner AK, Parkhill J, Charles IG, Maskell DJ, Stevens MP. 2013. Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals. PLOS Genetics. Apr;9(4):e1003456.
  5. Wang J, Chaudhuri RR, Ellar DJ. 2010. Characterization of ISBth4, a functional new IS231 variant from Bacillus thuringiensis MEX312. Plasmid. 63: 46-52
  6. Buckley AM, J*. Wang, DL Hudson, AJ Grant, MA Jones, DJ Maskell and MP Stevens. 2010. Evaluation of live-attenuated Salmonella vaccines expressing Campylobacter antigens for control of C. jejuni in poultry. Vaccine, 28(4):1094-105. (* joint first author)
  7. Peters S.E., G.K. Paterson, E.S.D. Bandularatne, H.C. Northen,S. Pleasance,C. Willers, J. Wang, A.K. Foote, F. Constantino-Casas, T.J. Scase, B.A. Blacklaws, C.E.Bryant, P. Mastroeni, I.G. Charles and D.J. Maskell. 2010. Salmonella enterica serovar Typhimurium trxA mutants are protective against virulent challenge and induce less inflammation than the live-attenuated vaccine strain SL3261. Infection and Immunity 78(1):326-36.
  8. Wang J., Steggles J. R.and D. J. Ellar. 2008. Molecular characterization of virulence defects in Bacillus thuringiensis mutants. FEMS Microbiology Letters 280: 127–134.
  9. Wang J., Gardiol, N., Burr. T., Salmond. G. P. and Welch. M. 2007. RelA-dependent (p)ppGpp production controls exoenzyme synthesis in Erwinia carotovora subsp. Atroseptica. Journal of Bacteriology. 189(21):7643-52.
  10. Smith, D., Wang, J., Swatton, J. E., Davenport, P., Price, B., Mikkelsen, H., Stickland, H., Nishikawa, K., Gardiol, N., Spring, David R. and Welch, M. 2006. Variations on a theme: diverse N-acyl homoserine lactone-mediated quorum sensing mechanisms in gram-negative bacteria. Review. Science Progress 89 (Pt 3-4):167-211.
  11. Steggles J. R., J. Wang*, and D. J. Ellar. 2005. Discovery of virulence genes of Bacillus thuringiensis using signature-tagged mutagenesis in an insect model of septicaemia. Current Microbiology. 53, 303-310. (*Corresponding author)
  12. Chen Y. H.,Y.Y. Deng, J. Wang, J. Cai, and G. X. Ren. 2004. Melanin produced by a wild-type strain of Bacillus thuringiensis.   Journal of General and Applied Microbiology. 50(4).401
  13. Chen Y. H., H. X. Li, J. Wang, J. Cai, and G. X. Ren. 2004. Cloning of full cry1C gene from Btc and expression in crops beneficial bacteria Bacillus cereus. Acta Microbiologica Sinica. 31(1), 65-68.
  14. Wang J., A. Boets, J. Van Rie and G. X. Ren. 2003. Characterization of cry1, 2 and 9 genes in Bacillus thuringiensis isolates from China. Journal of Invertebrate Pathology, 82: 63–71.
  15. Wang J., Y. H. Chen, G. X. Ren and Y. X. Huo. 1999. Isolation and characterization of gene types in a Bacillus thuringiensis strain collection of China. Oral presentation. Biotechnology of Bacillus thuringiensis. Beijing, Science Press. Vol.3: 95-96.  The III Pacific Rim Conference on the Biotechnology of Bacillus thuringiensis and its Environmental Impact, Wuhan, China.

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